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Biomedical subjects

A Al-Juburi

Publications and source records attributed to A Al-Juburi.

5 recordsLinked to original sources
PubMed1980

The varicocele: new experimental and clinical data.

Numerous reports have shown that serotonin (5-HT) has a detrimental effect on spermatogenesis and androgen synthesis. Serotonin has two mechanisms of action on the testicle: (1) vasoconstrictive changes possibly causing premature sloughing of spermatozoa, and (2) alteration of androgen metabolism. The data in our animals with the experimental varicocele clearly mimic the human situation. All seminal parameters except volume are decreased after the varicocele is created. In many infertile patients with a varicocele, serotonin may be the inciting factor which results in subfertile semen. This is corroborated by the presence of elevated serotonin levels in spermatic vein plasma of most patients with a varicocele who undergo surgery. More data, comparing the relationship between spermatic vein and peripheral blood serotonin levels in patients with and without a varicocele, are needed. This investigation is being pursued in patients undergoing inguinal surgery for other lesions.

Animals↗
PubMed1980

The varicocele: elevated serotonin and infertility.

Serotonin is known to be toxic to testicular function. In a series of canine studies serotonin was found to be elevated in both spermatic veins after creation of a varicocele by partial ligation of the left renal vein. A total of 42 consecutive infertile male patients with a palpable varicocele and a seminal stress pattern had peripheral and spermatic vein serotonin levels determined at the time of high spermatic vein ligation. Of these patients 27 (64 per cent) had spermatic vein serotonin levels equal to or greater than peripheral levels. These patients demonstrated significantly lower sperm motility, percentage of live sperm and elevated percentages of immature and tapered sperm forms compared to those patients with lower spermatic vein serotonin levels. The interrelationships among the varicocele, premature sloughing of immature sperm and serotonin are discussed.

Animals↗
PubMed1979

Alteration of semen quality in dogs after creation of varicocele.

A left vein varicocele was created in male dogs by partially obstructing the left renal vein medial to the entrance of the left internal spermatic vein. Eight dogs had semen parameters determined preoperatively (2 times/week for five weeks) and postoperatively (2 times/week for twelve weeks). Semen quality was altered by the experimental varicocele. A significant decrease in sperm count, motility, per cent viable, and per cent oval sperm were noted. Semen volume was not affected. The possible chemical influence of serotonin is mentioned. Testosterone levels were unchanged by the varicocele. Histologic findings in the left and right testicles are mentioned before and after creation of the varicocele.

Animals↗
PubMed1979

The varicocele: a critical analysis of experimental and clinical data.

A number of reports have shown that serotonin has a detrimental effect on spermatogenesis and androgen synthesis. Serotonin has 2 mechanisms of action on the testicle: 1) vasoconstrictive changes and 2) direct alterations of testicular metabolism and endocrine activity. The data in animals with the experimental varicocele clearly mimic the human situation. All of the seminal parameters except volume are decreased after creating the varicocele. In many infertile patients with a varicocele serotonin may be the inciting factor that results in subfertile semen parameters. This is corroborated by the presence of elevated serotonin levels in spermatic vein plasma of certain patients with a varicocele. More data comparing the relationship between spermatic vein and peripheral blood serotonin levels in patients with and without a varicocele are needed. This investigation also is being pursued in patients undergoing inguinal operations for lesions other than a varicocele.

Animals↗