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Biomedical subjects

A Akaike

Publications and source records attributed to A Akaike.

At least 163 records · Page 9Linked to original sources
PubMed1978

Analgesia by enkephalins injected into the nucleus reticularis gigantocellularis of rat medulla oblongata.

Methionine-enkephalin (0.2--20 microgram/rat) and leucine-enkephalin (1--20 microgram/rat) produced a dose-related and naloxone-antagonizable analgesia in the tail-pinch test, when microinjected into the nucleus reticularis gigantocellularis (NRGC) and nucleus reticularis paragigantocellularis (NRPG) of the medulla oblongata of the rat. The median analgesic doses were 1.4 and 4.8 microgram/rat for methionine- leucine-enkephalin, respectively. The possibility that the endogenous enkephalins play a part as pain control substances or modulators in the NRGC and NRPG was discussed.

Analgesics↗
PubMed1978

Persistent atrial standstill developed in a patient with rheumatic heart disease: electrophysiological and histological study.

A case with persistent atrial standstill is presented which developed from atrial fibrillation associated with rheumatic combined valvular heart disease. In addition to clinical and electrocardiographic findings, electrophysiological and histological studies by using microelectrode technique and electron microscopy, respectively, were carried out on specimens from the right atrial appendage resected at mitral valve surgery. Scattered but severe loss of myocardial cells in the atria and deterioration of the action potential of these poorly sustained myocardial cells were confirmed. The suggestive evidence is also shown that the deteriorated action potential observed by micro-electrode technique in this case may be composed of calcium current.

Action Potentials↗
PubMed1977

Myocardial infarction due to metastasis of choriocarcinoma in a 29-year-old woman.

A rare and instructive case of myocardial infarction in a 29-year-old woman was presented. In this case it was clinically suspected that myocardial infarction was due to metastatic choriocarcinoma of the heart. This was confirmed by autopsy. It was emphasized that metastatic choriocarcinoma of the heart could be a cause of myocardial infarction in young women.

Adult↗
PubMed1977

Clinical significance of preoperative liver scintigraphy in gastric cancer.

The surgical and liver scintigraphic findings were compared for evaluation of preoperative diagnostic value in 146 cases of gastric carcinoma. Correct diagnosis was found in 95% with a false negative rate of 2.7% and a false positive rate of 27%. In all the false negative cases, the size of all space-occupying lesions within the liver was less than 3 cm. in diameter. In view of the high percentage of correct diagnosis (95%), we believe that the preoperative liver scintigraphy is very useful clinically. Furthermore, we documented that liver metastasis is a late complication of gastric cancer and suggest that new diagnostic tools are needed to assess the presence of nodal metastasis, serosal infiltration and peritoneal dissemination.

Adult↗
PubMed1976

Effects of indomethacin and the other anti-inflammatory agents on activation of dorsal horn cell in the spinal cord induced by intra-arterial injection of bradykinin.

Bradykinin (1-2 mug) injected into the femoral artery of the rabbit induced a marked increase in the firing rates of the dorsal horn cells (lamina V cells). This response was markedly inhibited by intravenous administration of indomethacin (1.0 mg/kg), acetylsalicyclic acid (20 mg/kg), aminopyrine (50 mg/kg) and oxyphenbutazone (20 mg/kg) in both intact and spinal preparations. Moreover, the intra-arterial injection of these agents depressed the response in lower doses. With these same low doses, no significant suppression occurred when the intravenous route was used. These results indicate that indomethacin and other anti-inflammatory agents tested suppress the bradykinin-induced response of the dorsal horn cell at the periphery, probably at the paravascular sensory nerve.

Animals↗
PubMed1976

Indirect and direct depressive effects of morphine on activation of lamina V cell of the spinal dorsal horn induced by intra-arterial injection of bradykinin.

Small doses of morphine (0.3-2.0 mg/kg i.v.) inhibited, in the majority of intact rabbits, the unitary activities of the lumbar lamina V dorsal horn neurons induced by intra-arterial injection of bradykinin, a potent pain producing substance, but not in spinal rabbits. A large dose of morphine (5.0 mg/kg), however, inhibited the bradykinin-induced response even in spinal rabbits. These results suggest that morphine, in small doses, inhibits the sensory transmission of bradykinin-induced pain at the dorsal horn of the spinal cord, through its facilitatory action on the descending inhibitory mechanism; in large doses the level of dorsal horn is directly inhibited.

Animals↗