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Biomedical subjects

A Aggarwal

Publications and source records attributed to A Aggarwal.

206 records · Page 12Linked to original sources
PubMedDate not supplied

Intraoperative epiaortic ultrasound during cardiac surgery.

BACKGROUND AND AIMS: Recent evidence suggests that the incidence of stroke during cardiac surgery may be reduced by using intraoperative epiaortic ultrasound (IEU) to detect ascending aortic atherosclerosis (AAA). To better define the role of this modality, IEU was performed in 89 patients during elective cardiac procedures. METHODS: The ascending aorta and proximal arch were divided into four segments that were graded (0 to 2) on the extent of disease both by palpation and IEU. A patient score (range 0 to 8) was determined for each modality by summing the segmental scores. Operative plan was determined in part by IEU findings. Preoperative variables were evaluated for associated risk of AAA. Palpation and IEU scores were compared for their ability to identify AAA. RESULTS: Operative technique was modified to avoid AAA in ten (11.2%) patients (mean age 68.3 +/- 2.2 years; mean IEU score = 4.40 +/- 0.40). Stroke occurred in two patients (2.2%), one whose operation was modified to avoid severe AAA and another who had minimal AAA. Mean IEU scores were significantly higher for patients > or = 65 years compared with younger patients (1.35 +/- 0.26 vs 0.66 +/- 0.21; p < 0.05) and for smokers compared with nonsmokers (1.15 +/- 0.19 vs 0 +/- 0; p < 0.05). Mean patient IEU score was greater than mean palpation score (1.06 +/- 0.18 vs 0.74 +/- 0.16; p < 0.05). Sensitivity of palpation (based on 356 segments) was 0.46; however, specificity was 0.96, predictive power of a negative palpation exam was 0.88, and overall accuracy of palpation was 0.86. Thirty of the 38 false negatives resulted from failure to detect 1+ disease. None of the 63 (71%) patients with a palpation score of zero required a technical modification or had a stroke. CONCLUSIONS: These data suggest that AAA may be more severe in older patients and smokers. Aortic palpation may not identify mild AAA. IEU can confirm and clearly define both the extent and distribution of suspected AAA and is useful for determining optimal operative strategy in patients with aortic disease.

Adult↗
PubMedDate not supplied

Functional protein C and anti-cardiolipin antibody in children with portal vein thrombosis.

BACKGROUND: Portal vein thrombosis (PVT) is a common cause of portal hypertension in children from developing countries. Deficiencies of proteins C and S and elevated anticardiolipin antibody (aCL) levels have been shown to predispose to venous thrombosis. We studied these factors in children with idiopathic PVT. METHODS: 19 children with PVT (mean [SD] age 5.7 [2.1] y; 15 boys) were studied; all had had variceal bleeding, and had PVT on ultrasonography. Functional protein C activity was measured using a clotting assay; if it was normal, a clotting assay for functional protein S activity was performed. IgG aCL levels were measured in all sera using an in-house standardized solid-phase ELISA. RESULTS: Protein C functional activity ranged from 4% to 109%. Eight children had activity below 70%, the lower cut-off of the normal range. Protein S assay, done in 10 of the 11 children with normal protein C activity levels, was normal (above the cut-off level of 65% of the normal range). IgG aCL levels were abnormally elevated (>mean + 2SD of 16 healthy control children) in nine children; of these, three had associated protein C deficiency. Thus, of the 19 children with idiopathic PVT, 14 had abnormality in one or more tests. CONCLUSION: A majority of children with PVT of unknown etiology have functional protein C deficiency or abnormally elevated levels of aCL antibodies.

Antibodies, Anticardiolipin↗
PubMedDate not supplied

Effects of passive smoking on outcome in pregnancy.

BACKGROUND: Adverse health effects of exposure to environmental tobacco smoke (ETS) among non-smokers have been studied occasionally in developing countries. AIMS: To study the effects of exposure to ETS on outcome in pregnancy SETTINGS AND DESIGN: A cross-sectional study at a secondary level teaching hospital Material and Methods: Consecutive 576 non-smoking women delivering a singleton live baby were studied. A pre-designed structured questionnaire was used to record the details of exposure to ETS at home. The maternal and foetal variables were compared among those who were exposed to ETS vis-à-vis not exposed. Unpaired Student t-test was used for the comparison of continuous variables and Fisher's Exact test was used for categorical variables. Multiple logistic regression analysis was performed after including all variables found to have significant differences on univariate analysis. RESULTS: Of the 576 women studied 141 (24%) were exposed to ETS. In the mothers exposed to ETS, there was a significantly higher incidence of pre-term birth (24.1% vs. 16.1%; P = 0.027) and small-for-gestation babies (31.9% vs.17.2%; p<0.001) as compared to unexposed mothers. The mean birth weight of the babies born to the mothers exposed to ETS was 138 g less than that of babies in the unexposed group (2632 -/+577 g vs. 2770 -/+562 g respectively, p = 0.014). The multiple logistic regression analyses showed that ETS exposure during pregnancy was significantly associated with a higher risk of small-for-gestation babies (OR 2.10; 95% CI: 1.27-3.48). CONCLUSION: Exposure to ETS during pregnancy is associated with higher risk of having a small-for-gestation baby.

Adult↗
PubMedDate not supplied

Compliance of secondary prophylaxis for controlling rheumatic fever and rheumatic heart disease in a rural area of northern India.

This study was conducted in a community development block of a district in Haryana to evaluate the compliance of secondary prophylaxis for controlling rheumatic fever (RF) and rheumatic heart disease (RHD). The patients were interviewed using a semi-structured schedule at home. Currently 110 patients are registered in RF/RHD registry of which 53 (48.2%) are males. Mean age of patients was 18.4 +/- 8.6 years, ranging from 6 to 50 years with majority (48, 43.7%) of patients in the age groups of 6-15 and 16-25 years. Out of 110 patients, more than 90 percent had taken 11 out of the 12 due doses of secondary prophylaxis every year in the last eight years of the programme except in 1995 when 92 (83.6%) patients took the prophylactic doses. Only one patient reported recurrent attacks of rheumatic fever after irregular secondary prophylaxis. Eighteen (16.4%) patients were defaulters at the time of interview and were motivated to take secondary prophylaxis regularly. Ninety-seven (88.2%) patients were satisfied with the ongoing programme. In developing countries, it is possible to successfully apply a secondary prevention programme for control of RF/RHD by using existing health infrastructure.

Adolescent↗