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Biomedical subjects

A Adam

Publications and source records attributed to A Adam.

At least 379 records · Page 21Linked to original sources
PubMed1969

L'acide N-glycolyl-muramique, constituant des parois de Mycobacterium smegmatis: Identification par spectrometrie de masse.

The repeating disaccharide unit of the mucopeptide of the cell wall of Mycobacterium smegmatis contains N-acetyl-glucosamine linked to N-glycolyl-muramic acid. This first identification of N-glycolyl-muramic acid as a natural product has been performed by mass spectrometry of the permethylated disaccharide. N-glycolyl muramic acid has been synthesized: the natural and synthetic products are identical.

Journal Article↗
PubMed1969

Granuloma formation induced in mice by chemically defined mycobacterial fractions.

Amounts of trehalose-6,6-dimycolate as small as 1 to 5 mug can, after intravenous injection, induce in the lungs of mice formation of tubercles in which the cellular composition is indistinguishable from that in tubercles formed after an infection with living BCG bacilli. The strongest cellular response in mice was induced by cord factor from Mycobacterium kansasii; the weakest was induced by cord factor from the BCG strain of M. bovis. It was found that three intravenous injections of cord factor induced a more extensive cellular response than did one injection of the same total amount of cord factor. Mice treated intravenously with cord factor were protected against an intravenous challenge with the virulent H37Rv strain of M. tuberculosis. The cellular response in the lungs of mice to intraperitoneal injections of living BCG and cord factor was very weak compared with that after intravenous injections. Intraperitoneal vaccination of mice with cord factor did not protect the mice against a challenge with virulent tubercle bacilli. Mice vaccinated intraperitoneally with BCG were immunized although no granulomas, or very few, were present in the lungs at the time of the challenge. The significance of the cellular response induced by cord factor is discussed.

Animals↗