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Biomedical subjects

A Adam

Publications and source records attributed to A Adam.

At least 343 records · Page 19Linked to original sources
PubMed1975

Isolation of mitogenic and adjuvant active fractions from various species of Nocardiae.

Delipidated lysozyme digests of Nocardia opaca, N. corallina, and N. rubra have been fractionated by Sephadex filtration. The mitogenic and adjuvant activities of the fractions thus obtained have been investigated. All fractions are mitogenic except the last fraction of N.rubra, but the N. opaca products induce a stronger stimulation of mouse spleen lymphocytes than the corresponding fractions of the two other species. The activity of the first Sephadex fractions of each strain has been compared to other mitogens (concanavalin A, lipopolysaccharide). All fractions are adjuvant, although one of them, the last Sephadex fraction of N. rubra, does not contain peptidoglycan; its activity must thus be attributed to another kind of molecule. Fractionation of the first Sephadex fraction of N. opaca by centrifugation in glacial acetic acid led to a separation of adjuvant and mitogenic activities.

Adjuvants, Immunologic↗
PubMed1975

Dissection and rupture of the ascending aorta. Unusual complications of aortocoronary bypass surgery.

This is a report concerning two cases of unusual complications, dissection and rupture of the ascending aorta, secondary to saphenous vein bypass surgery. We recommend that evaluation of patients undergoing saphenous vein bypass surgery include careful image-intensifier fluoroscopic examination during coronary arteriography. If aneurysmal dilatation of the aorta or calcification is observed, ascending aortography should be performed to better evaluate the aorta, and surgeons should be alerted to use appropriate maneuvers and techniques to minimize the risk of complications in the aortic site of the vein anastomosis. Internal mammary coronary-artery bypass should be the procedure of choice in such conditions.

Aortic Aneurysm↗
PubMed1975

Peptidoglycan adjuvants: minimal structure required for activity.

The chemical structure of the adjuvant active fraction of mycobacterial cell walls has been investigated. It had been shown previously that soluble peptidoglycan fragments obtained from cell walls of Mycobacteria by lysozyme digestion or by other treatments act as adjuvants for increasing both humoral and cellular immunity. We then found that even the monomer subunit of the peptidoglycan of Mycobacteria (i.e. a disaccharide-tetrapeptide) is adjuvant active; then, similar compounds from other strains of bacteria were tested; the monomeric subunits of meso-diaminopimelic acid as well as L-lysine containing peptidoglycans were found to be adjuvant active. The smallest active compound studied so far is N-acetyl-muramyl-L-alanyl-D-isoglutamine synthesized for us by SINAY et al. (1975).

Adjuvants, Immunologic↗
PubMed1974

Glomerular nodules and long-spacing collagen in kidneys of patients with multiple myeloma.

Light microscopic examination of the kidneys in 170 patients with multiple myeloma revealed three from patients without diabetes with glomerular nodules that were indistinguishable from those of diabetic glomerular sclerosis. Electron microscopic studies showed the nodules to be deposits of fine-grained material that corresponded to precipitations of protein but lacked the basement-membrane-like material characteristic of nodular glomerulosclerosis in diabetics. What is more, a unique collagen was observed in the marginal area of the nodules and in the periglomerular interstitium. The possible causes of the origin and distribution of this collagen not so far described in the human kidney are discussed.

Aged↗