Biomedical subjects

A Abarca

Publications and source records attributed to A Abarca.

8 recordsLinked to original sources

PubMed2001

Determination of iron and molybdenum in a dietetic preparation by flame AAS after dry ashing.

Methods for the determination of iron and molybdenum in a dietetic pharmaceutical preparation by flame atomic absorption spectrometry (FAAS) after dry ashing at 600 degrees C have been validated. Linearity, precision, accuracy, detection and quantification limits, specificity and robustness have been determined. Linearity of response was verified for concentrations ranging from 0.50 to 4.00 mg l(-1) of iron and 1.00 to 6.00 mg l(-1) of molybdenum. Precision of the methods, performed under conditions of repeatability and reproducibility, gave relative standard deviations of 0.4 and 1.1%, respectively, for the iron determination and of 1.0 and 6.5%, respectively, for the molybdenum determination. Mean recoveries determined after spiking dietetic preparation placebos ranged from 97.1 to 102.6% for iron and 95.2 to 102.9% for molybdenum. The limit of detection for iron was 126 microg g(-1) and for molybdenum 129 microg l(-1). Quantification limits were 420 and 433microg l(-1) for iron and molybdenum, respectively. No interference in the iron and molybdenum determination due to other components present in the dietetic capsules was found. Day-to-day and analyst-to-analyst variability was less than 1.1% for iron and 4.5% for molybdenum. Results show the suitability of the method for measurement of iron and molybdenum in a complex matrix sample such as a dietetic pharmaceutical preparation.

Dietetics↗

PubMed2001

A validated flame AAS method for determining magnesium in a multivitamin pharmaceutical preparation.

A rapid method for determining magnesium in a multivitamin pharmaceutical preparation has been validated. This element is analysed by flame atomic absorption spectrometry after dissolution of the sample in acid medium. Linearity, precision, accuracy and robustness of the method have been determined, and detection and quantification limits have been calculated. Linearity of response was verified for concentrations ranging from 0.05 to 0.40 mg x l(-1) of magnesium. Correlation coefficient of the calibration straight lines was always > or =0.9999. Repeatability of the method gave relative standard deviation (R.S.D.) of 0.6%. Reproducibility of the method calculated after analysis of samples by the same analyst in different days (day-to-day fluctuation) and by two different analysts in different days (analyst-to-analyst fluctuation) gave relative standard deviation of 1.1 and 1.6%, respectively. Mean recoveries of magnesium obtained after spiking sample placebos with increasing amounts of magnesium chloride ranged from 98.9 to 100.8%. Robustness of the method evaluated by changing different experimental conditions under which analyses were performed, gave relative standard deviation from 0.2 to 0.5%. Limits of detection and quantification were 3.8 and 7.0 microg of Mg per gram of sample, respectively. Results show the suitability of the method for direct measurement of magnesium in a water-soluble multivitamin pharmaceutical preparation.

Magnesium↗

PubMed2001

Optical measurement of cardiac rhythm using a personal computer with telediagnosis possibilities.

A system that enables the automatic measurement of cardiac rhythm and the quantity of oxygen in the blood has been designed, constructed, and patented. Equipped with the appropriate software, this system registers this information and represents it numerically, in the form of a graph, which can then be printed as a detailed record of cardiac rhythm. This system aids in the determination of cardiac pathologies, and also enables the information to be sent to medical professionals to perform telediagnosis. The apparatus is based on the measurement (sampling) of noninvasive medical parameters. The apparatus is intended to cover a broad range of requirements and needs, as can be used by medical professionals (to detect pathologies related to the pumping and circulation of blood in the body) as well as by lay people who might wish to monitor or gain information concerning their cardiac rhythm and the general functioning of their heart. Thus, the system is designed to be clear and concise in its information as well as easy to use, especially for people unrelated to the medical profession. The way to constructing this system is explained in detail.

Cardiovascular Diseases↗

PubMed2000

[{Ti]

Explore the source record for details and available documents.

Journal Article↗

PubMed2000

Ammonolysis of mono(pentamethylcyclopentadienyl) titanium(IV) derivatives.

Ammonolyses of mono(pentamethylcyclopentadienyl) titanium(IV) derivatives [Ti(eta5-C5Me5)X3] (X = NMe2, Me, Cl) have been carried out in solution to give polynuclear nitrido complexes. Reaction of the tris(dimethylamido) derivative [Ti(eta5-C5Me5)(NMe2)3] with excess of ammonia at 80-100 degrees C gives the cubane complex [[Ti(eta5-C5Me5)]4(mu3-N)4] (1). Treatment of the trimethyl derivative [Ti(eta5-C5Me5)Me3] with NH3 at room temperature leads to the trinuclear imido-nitrido complex [[Ti(eta/5-CsMes)(mu-NH)]3(mu3-N)] (2) via the intermediate [[Ti(eta5-C5Me5)Me]2(mu-NH)2] (3). The analogous reaction of [Ti(eta5-C5Me5)Me3] with 2,4,6-trimethylaniline (ArNH2) gives the dinuclear imido complex [[Ti(eta5-C5Me5)Me])2(mu-NAr)2] (4) which reacts with ammonia to afford [[Ti(eta5-C5Me5)(NH2)]2(mu-NAr)2] (5). Complex 2 has been used, by treatments with the tris(dimethylamido) derivatives [Ti(eta5-C5H5-nRn)(NMe2)3], as precursor of the cubane nitrido systems [[Ti4(eta5-C5Me5)3(eta5-C5H5-nRn)](mu3-N)4] [R = Me n = 5 (1), R = H n = 0 (6), R = SiMe3 n = 1 (7), R = Me n = 1 (8)] via dimethylamine elimination. Reaction of [Ti(eta5-C5Me5)Cl3] or [Ti(eta5-C5Me5)(NMe2)Cl2] with excess of ammonia at room temperature gives the dinuclear complex [[Ti2(eta5-C5Me5)2Cl3(NH3)](mu-N)] (9) where an intramolecular hydrogen bonding and a nonlineal nitrido ligand bridge the "Ti(eta5-C5Me5)Cl(NH3)" and "Ti(eta5-C5Me5)Cl2" moieties. The molecular structures of [[Ti(eta5-C5Me5)Me]2 (mu-NAr)2] (4) and [[Ti2(eta5-C5Me5)2Cl3(NH3)](mu-N)] (9) have been determined by X-ray crystallographic studies. Density functional theory calculations also have been conducted on complex 9 to confirm the existence of an intramolecular N-H...Cl hydrogen bond and to evaluate different aspects of its molecular disposition.

Journal Article↗

PubMed2000

Construction of Heterometallic Cubanes

Incorporation of M(CO)(3) fragments by trinuclear Ti complexes [{Ti(3)Cp<![IGNORE[$\curr {\brol{{\stern}}{3}}$]]>(µ(3)-CR)}(µ-O)(3)] and [{Ti(3)Cp<![IGNORE[$\curr {\brol{{\stern}}{3}}$]]>(µ(3)-N)}(µ-NH)(3)] (Cp*=eta(5)-C(5)Me(5)) leads to the formation of an unprecedented class of heterometallic clusters with cubane structure [e.g., Eq. (a)]. Density functional calculations on these complexes indicate the existence of electron delocalization in the Ti(3)M cores (M=Cr, Mo, W).

Journal Article↗

PubMed1996

Hyperopia correction by noncontact holmium:YAG laser thermal keratoplasty. Clinical study with two-year follow-up.

BACKGROUND: Thermal keratoplasty to correct hyperopia has been attempted with nonlaser and laser devices. Problems have included long-term regression and irregular induced astigmatism. The present clinical study was performed to investigate the safety, efficacy, and stability of a noncontact mode of holmium: YAG laser energy delivery and a modified laser thermal keratoplasty treatment procedure for correction of low hyperopia. METHODS: Seventeen patients underwent noncontact holmium: YAG laser thermal keratoplasty in their nondominant eyes for correction of hyperopia of up to 3.00 diopters. Treatment parameters included simultaneous delivery of eight holmium: YAG laser spots in a symmetrical octagonal array with a centerline diameter of 6mm, 10 pulses of laser light at 5-Hz pulse repetition frequency, and pulse energies of 159 to 199mJ. Follow-up was 2 years in 15 of 17 patients. RESULTS: In the 15 eyes examined at 2 years after surgery, mean uncorrected distance Snellen visual acuity improved from 20/125-1 to 20/50-2. The mean change in spherical equivalent of subjective manifest refraction was -0.79 diopter. Eleven of these 15 eyes (73%) had a mean refractive correction of -1.1 diopters (range, -0.38 to -2.63 diopters); regression between 14 days and 2 years was 0.2 diopter. Four eyes (27%) had no persistent refractive correction (within +/- 0.25 diopter). Mean induced refractive astigmatism was 0.18 diopter. None of the eyes lost two or more lines of spectacle-corrected distance vision. The amount of refractive correction at 2 years after surgery was correlated to the treatment pulse energy and the volume of the opacified corneal tissue observed immediately after treatment. CONCLUSIONS: This technique of noncontact laser thermal keratoplasty produced safe, effective, and persistent corrections of low hyperopia in the majority of treated eyes.

Aged↗

PubMed1996

Corneal topographic changes and induced astigmatism resulting from superior and temporal scleral pocket incisions.

BACKGROUND AND OBJECTIVE: To determine the corneal topographic changes that are induced by superior and temporal 5-mm scleral pocket incisions. PATIENTS AND METHODS: The authors retrospectively reviewed the records of 43 patients who underwent phacoemulsification with posterior chamber lens implantation through unsutured 5-mm scleral pocket incisions, 24 superiorly and 19 temporally. Corneal curvature was measured using computerized videokeratography, and the induced astigmatism was calculated with the Holladay-Cravy-Koch formula. RESULTS: At 4 to 6 weeks, postoperatively there was mild flattening along with the meridian of the incision in both groups. The change was greater with the superior incisions, but the differences between the groups were not statistically significant. Surgically induced astigmatism was 0.7 D (+/-0.1 D) in the eyes that received superior incisions, and 0.3 D (+/-0.1 D) in the eyes that received temporal incisions; this difference was statistically significant (P < .03). CONCLUSIONS: At 4 to 6 weeks postoperatively, temporal 5.0-mm scleral pocket incisions provide more stable postoperative topography than do superior scleral pocket incisions.

Adult↗