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Biomedical subjects

A A Shutov

Publications and source records attributed to A A Shutov.

At least 19 recordsLinked to original sources
PubMed1999

[Diagnostic value of rosette-forming acetylcholine specific lymphocytes in the blood of myasthenia gravis patients].

In a blood of 37 patients with different forms of myasthenia (M) there was found an increase of a number of rosette-forming lymphocytes specific to acetylcholine in a specific rosette-forming reaction with acetylcholine erythrocytes' diagnostic kit. A value of this index correlated with a duration of the disease, with a degree of its generalization, with a degree of its severity and with the type of myasthenic process' course. Meanwhile, it wasn't depended on the age of the patients. In a blood of both healthy individuals and the patients with some other neurologic diseases a number of rosette-forming lymphocytes specific to acetylcholine was considerably lower. A number of the lymphocytes specific to acetylcholine was increased even in the debut of M and remained altered during all the period of the disease. That may serve as an additional diagnostic marker of M in any age, at different character and severity of the disease, in any phase of this pathology.

Acetylcholine↗
PubMed1996

[Pathology of the hemostatic system in the acute period of an ischemic stroke and the possibilities for its therapeutic correction].

The indices of blood haemostasis adequately reflecting the state of coagulative, fibrinolytic, anticoagulative and platelet aggregation systems were examined in 150 patients with acute ischemic stroke. The four haemostasiological syndromes such as hyperaggregation, hypercoagulation, depressed fibrinolysis, hypercoagulation and three types of thrombophilias were distinguished and described in detail. The special features of coagulopathic disorders depending on etiology, severity and stroke onset period were characterized. The authors developed some recommendations on selective medical correction of haemostatic disorders in acute period of brain infarction.

Acute Disease↗
PubMed1993

[Multiple sclerosis: acute state or malignant course?].

Multiple sclerosis (MS) which had developed in a 19-year-old female patient took a malignant course and terminated fatally three years after first symptoms. The case was characterized by an acute onset, seven severe exacerbations against combined pyramidal, cerebellar, visual, psychopathological and hyperkinetic disorders. The authors believe improper application of the term "acute" to rapid lethal outcome cases. In their opinion, they should be called cases of MS malignant course, the latter implying an unfavourable outcome of MS due to primarily truncal location of the demyelination process.

Acute Disease↗
PubMed1993

[Thyroid function in brain concussion].

RIA was used to study the quantitative content in the blood serum of thyrotropic (TTH), thyroid (total thyroxine (T4), free thyroxine, triiodothyronine (T3) hormones and thyroxine-binding capacity of blood plasma proteins in 30 patients with brain concussion from the first to the 12th day of disease. The patients' hormonal profile was characterized by normal characteristics of TTH, depression of the transport organic phase of thyroid metabolism with a decrease of the T4 concentration, a reduction of the thyroxine-binding capacity of plasma protein, and simultaneous activation of the peripheral stage of iodine metabolism with excess accumulation in the blood of active hormones--free thyroxine and T3. The data obtained deepen our understanding of the pathogenesis of craniocerebral injury (CCI). The neuroendocrine syndrome identified is specific for mild CCI. It can be used as a differential diagnostic criterion for expert medical evaluation purposes.

Adolescent↗
PubMed1993

[A case of Rud's syndrome].

A twenty-two-year-old patient is described who developed in the presence of congenital ichthyosis, osseous system developmental abnormalities, and psychopathologic personality disorders fits with loss of consciousness and seizures whose epileptic nature was proved by EEG studies. Clinical symptom complex found in this patient conformed to description of a rare hereditary disease, Rud's syndrome. The role of hereditary abnormalities in epilepsy development is discussed, as are problems of differential diagnosis of Rud's syndrome and other rare hereditary diseases with combinations of ichthyosis, epilepsy, and intellect disturbances.

Adult↗
PubMed1993

[The Kearns-Sayre syndrome].

The paper describes Kearns-Sayre's syndrome, a rare hereditary neuromuscular disease, in a patient aged 17 years. The clinical picture of the disease had a classical triad: external ophthalmoplegia, pigmentary retinopathy, and cardiac conduction disturbances. This triad was supplemented with other polymorphous symptoms characteristic of the syndrome, such as moderate myopathic syndrome, hemeralopia, physical infantilism, hypogonadism, pyramidal syndrome. Bifascicular block in the His-Purkinje system was accompanied by mitral prolapse. The problems of early diagnosis of the syndrome and choice of adequate therapeutical methods are discussed.

Adolescent↗
PubMed1993

[A psychoautonomic syndrome in duodenal peptic ulcer patients and its correction by magnetic puncture using an alternating magnetic field].

86 duodenal ulcer patients were diagnosed to have serious psychovegetative disorders. Among other treatment, the patients were exposed to AMF puncture of biologically active points. The puncture produced optimization of the function of cerebral (suprasegmental) vegetative structures, promoted a regress of vegetative dystonia clinical symptoms and speeded up ulcer healing.

Acupuncture Points↗
PubMed1993

[The cerebrovascular manifestations of temporomandibular joint pain dysfunction].

Overall 37 patients with painful dysfunction of the temporomandibular joint (TMJ), characterized clinically by headaches and dizziness as well (25 persons) were examined. A study was made of REG. The responsiveness of the sinocarotid node (SCN) was recorded. Diverse changes in the REG readings that attested to the development of cerebral angiodystonia were recorded. Abnormal responsiveness of SCN was discovered. Skillful orthopedic correction of the spatial position of the mandible was associated with noticeable changes in the normalizing and optimizing character of numerous REG readings. These data together with optimization of the responsiveness of the SCN point to the role played by the irritative vascular mechanism in the pathogenesis of headaches and dizziness seen in TMJ dysfunction.

Adolescent↗
PubMed1992

[A psychoautonomic syndrome in the residual period of a modern "mild" military craniocerebral trauma].

As many as 18 patients with a history of military service in Afghanistan, who suffered (7.2 years before on the average) commotion due to the explosion wave were examined. The vegetative status was studied by different methods including cardiointervalography, as was the patients' emotional and personality sphere. The data obtained were compared to those obtained in three control groups (practically healthy subjects; those who suffered a mild home craniocerebral injury; healthy subjects who fought in Afghanistan and were not victims to craniocerebral injury). The main group patients demonstrated noticeable changes in the vegetative tone, vegetative reactivity and vegetative supply to physical activity as well as a high level of anxiety, which forms vegetodystonia. Attempts were made to correct the psychovegetative syndrome by central electroanalgesia in the tranquilization mode (9-10 daily sessions). The lowering of the tension of regulatory body systems functioning and the reduction of anxiety and depression tendencies were recorded.

Adult↗
PubMed1992

[Autonomic disorders in the formation of the clinical manifestations of the initial forms of cerebrovascular lesions].

Among 103 persons aged 20 to 57 years, related occupationally to emotional stress, 48 persons were found to have vegetative dystonia, 28 initial manifestations of cerebral circulation failure, and 27 persons appeared healthy. The determination of the character and intensity of vegetative manifestations has shown that in the formation of vegetative dystonia, of paramount importance are cardiovascular and gastrointestinal disorders. Vegetative manifestations associated with initial manifestations of cerebral circulation failure include, in addition, respiratory disturbances and impairment of sleep function, which may reflect more deep changes in the activity of the regulatory apparatus in dyshemias of organic nature. A relationship was discovered between vegetative lesions and emotional disorders, particularly the level of anxiety, as was the contingency of vegetative dysfunction and decreased emotional stress tolerance.

Adult↗
PubMed1992

[Compression-ischemic peroneal neuropathy].

The clinical picture is described of 4 patients with the syndrome of lesion of the peroneal developing during fixation of some physiological postures (squatting position etc.). The pathogenetic mechanisms of the disease are discussed. The authors report a characteristic monotypical clinical symptom complex of compression-ischemic peroneal neuropathy.

Acute Disease↗
PubMed1992

[The efficacy of lincomycin in tick-borne encephalitis].

Lincomycin was found to inhibit tick-borne encephalitis (TBE) virus. To test antiviral potential of this drug, a clinical trial was initiated entering TBE patients from known focuses of the disease (Novosibirsk, Kemerovo, Perm and Irkutsk Provinces). The drug was given to 23 patients with meningeal and meningoencephalitic TBE. A control group of 22 matched subjects received specific immunoglobulin. Resultant efficacy of lincomycin appeared not inferior to that of anti-TBE immunoglobulin. Lincomycin can be successfully introduced in the treatment of meningeal and meningoencephalitic TBE.

Adolescent↗
PubMed1991

[Hemostasis in patients with ischemic stroke].

Modern informative techniques were employed to explore the coagulation, fibrinolytic and aggregation platelet systems of hemostasis in 117 patients in the most acute , acute, early, late restorative and residual periods of ischemic brain stroke. Disorders of the hemostatic system in the form of hyperaggregation, hypercoagulation, depression of fibrinolysis, and an increase of blood viscosity were revealed as were some specific features marking different period of brain stroke. Mono- and multi-systemic disorders of hemocoagulation and three types of coagulopathies were distinguished. Emphasis is laid on the necessity and feasibility of a goal-oriented selective correction of the pathological conditions of hemostasis at different periods of brain stroke by means of administering appropriate drugs.

Acute Disease↗
PubMed1991

[Characteristics of cerebrovascular circulation and its regulation in early stages of cerebrovascular disorders].

Cerebral circulation studied in 121 patients with early signs of cerebrovascular insufficiency exhibited typical asymmetric slowing down which started in distal compartments of the cerebral vascular bed and advanced to predominance in the vertebrobasilar circulation. Autoregulation of the circulation was preserved though hemodynamic requirements of emotional, mental and physical activity were not met completely. Initial discirculatory encephalopathy involves generalization of dysgemic shifts with progressive circulatory slowing down along the internal carotid arteries. In this case autoregulation gets disturbed in inhibited cerebrovascular reactivity.

Adult↗
PubMed1990

[Arterial hypotension and the initial manifestations of cerebral circulatory failure].

A study was made of the health status of 20 persons examined for the first time 10 years before for a long-term and steady decrease of arterial pressure classified at that period as vegetodystonia of the neurotic character. 71 healthy test subjects served as a reference group. In addition to the clinical examination, a specialized questionnaire was used to examine the status of the vegetative nervous system; the actual mental status and personality traits were investigated by the MIL test modified by F. B. Berezin and M. P. Miroshnikov; the level of reactive and personality anxiousness were estimated with the aid of Spilberger's scale; the life events and changes were assessed as well. It has been revealed that vegetodystonia recorded in the disease history produces no effect on the frequency and times of the appearance of the initial manifestations of cerebral circulatory failure (IMCCF). At the same time the intensity of vegetative disorders in the structure of the clinical manifestations of the IMCCF was higher in persons, in whose disease histories vegetodystonia was recorded.

Adult↗
PubMed1990

[The cerebral mechanisms of the autonomic disorders in vibration disease].

The status of the nonspecific brain systems was analyzed in 72 miners. Of these, 41, were in the premorbid stage and 31 were with the initial manifestations of vibration disease that occurred as a result of exposure to local vibration. The miners demonstrated dysfunction of the limbic-reticular complex in the form of concomitant vegetative, psychoemotional and nonspecific activation shifts. The syndrome of vegetative dystonia characteristic of the early (preclinical and manifest) nonspecific manifestations of vibration disease was a clinical reflection of cerebral dysfunction.

Adult↗
PubMed1990

[Changes in cerebral blood circulation and their correction in the interparoxysmal period of epilepsy].

The linear cerebral blood flow (LCBF) was explored in 75 patients with epilepsy according to 131I-albumin transition. LCBF acceleration on the side of the focus, during which the attacks occur rarely and the background EEG remains unchanged is regarded as the most adequate LCBF. The grave course of epilepsy is associated with a decrease of the LCBF on the side of the focus. The pattern of LCBF alterations depends as well on the form of epilepsy. Subclinical activation of the epileptic focus by corasole or hyperventilation gives rise to an increase of the LCBF on its side in patients with generalized secondary epilepsy, to a lowering in temporal epilepsy, and the lack of dynamics in the precentral disease pattern. Correction of the hemodynamic disorders can be attained with the aid of combining phenobarbital and caffeine or papaverine. The pathogenetic importance of the hemodynamic disorders is discussed in connection with functional hypoxia of neurons.

Adolescent↗