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Biomedical subjects

A A Scott

Publications and source records attributed to A A Scott.

32 records · Page 2Linked to original sources
PubMed1978

Extracorporeal membrane oxygenator support for human lung transplantation.

Extracorporeal membrane oxygenator (ECMO) support was provided for a 19-year-old boy undergoing right lung transplantation. Perfusion was begun several hours prior to transplant, to correct profound hypercapnia. After the operation, ECMO was required because of inadequate gas exchange by the transplanted lung. Perfusion was continued for a total of 96 hours. During this time, the temporary malfunction of the transplanted lung owing to the reimplantation response reversed, and the patient was successfully removed from the oxygenator and subsequently weaned from the ventilator. He died on the eighteenth postoperative day of bronchial dehiscence. ECMO support appears to be a feasible means of supporting patients during lung transplantation and during the period of reversible lung malfunction that may occur in the early postoperative period.

Adult↗
PubMed1977

Selective tracheobronchial aspiration.

Eighty attempts at placing suction catheters in the left main bronchus were analysed by studying chest radiographs. When angled catheters were used via a tracheostomy tube the success rate was 75%; the rate fell to 15% when straight tubes were used through an orotracheal tube. Assessment and control of the tube length was found to be important to avoid kinking and subsequent obstruction of the catheters.

Bronchi↗
PubMed1976

Systemic infection with Alaria americana (Trematoda).

Alaria americana is a trematode, the adult of which is found in mammalian carnivores. The first case of disseminated human infection by the mesocercarial stage of this worm occurred in a 24-year-old man. The infection possibly was acquired by the eating of inadequately cooked frogs, which are intermediate hosts of the worm. The diagnosis was made during life by lung biopsy and confirmed at autopsy. The mesocercariae were present in the stomach wall, lymph nodes, liver, myocardium, pancreas and surrounding adipose tissue, spleen, kidney, lungs, brain and spinal cord. There was no host reaction to the parasites. Granulomas were present in the stomach wall, lymph nodes and liver, but the worms were not identified in them. Hypersensitivity vasculitis and a bleeding diathesis due to disseminated intravascular coagulation and a circulating anticoagulant caused his death 8 days after the onset of his illness.

Adult↗
PubMed1976

Combination of membrane oxygenator support and pulmonary lavage for acute respiratory failure.

A 24-year-old woman with chronic granulocytic leukemia and alveolar proteinosis required extracorporeal membrane oxygenator support for respiratory failure refractory to conventional therapy. During perfusion, each lung was lavaged with 10 L. of normal saline. The lavage led to marked clearing of the lungs and improvement in pulmonary function. Extracorporeal support was terminated successfully after 54 hours. The patient died 2 weeks later with bone marrow insufficiency and overwhelming sepsis. Pulmonary lavage is technically feasible during venovenous oxygenator bypass, and may be of value, since such lavage debrides alveoli as well as the bronchial tree. Because pulmonary lavage provides a possible means of improving pulmonary function, it seems worthy of consideration as an adjunct to membrane oxygenator support.

Adult↗
PubMed1976

Cardiorespiratory failure secondary to peripheral pulmonary emboli. Survival following a combination of prolonged extracorporeal membrane oxygenator support and pulmonary embolectomy.

A 19-year-old woman developed cardiorespiratory failure from multiple, peripheral pulmonary emboli apparently developing over the preceding 3 weeks. She was not considered to be an operative candidate. However, when 3 days of intravenous heparin infusion and 30 hours of membrane oxygenator support failed to improve the pulmonary pathology, pulmonary embolectomy was performed. The membrane oxygenator support had to be continued for 34 hours following the operation before it was successfully discontinued. The patient made a complete recovery.

Adult↗
PubMed1975

Measurement of intratracheal oxygen concentrations during face mask administration of oxygen: a modification for improved control.

Direct measurement of the inspired tracheal oxygen concentration was made in patients breathing through standard aerosol face masks. Factors affecting the tracheal FIO2 were analyzed using both mechanical and mathematical models. When oxygen is delivered to the face mask at low flow rates, there is considerable patient variation in the measured tracheal FIO2. Delivery of oxygen at higher flow rates (15 litres per minute or greater), reduces such variation. Furthermore, turbulent air currents within and around the face mask reduce the measured FIO2 and contribute to fluctuations in the FIO2. This effect may be virtually eliminated by placing shields around the mask orifices as described. Using the shielded mask, it is possible to deliver the desired oxygen concentration to the patient more accurately and to maintain humidification of the delivered gases. Changes desired in inspired oxygen concentration are accomplished by changing the concentration of the incoming gas mixture, and not by merely changing the flow rate of oxygen delivered to the system. Using the shielded mask, it is possible to deliver an inspired oxygen concentration of 100 per cent. This is not true with most other commonly used face masks, and, therefore, caution should be used to avoid administration of unnecessary high inspired oxygen concentrations with this type of mask.

Air Movements↗
PubMed1973

Fat embolism: a rational approach to treatment.

Fat embolism following major trauma may be associated with a clinical syndrome with widespread pulmonary and systemic manifestations, the most serious being profound hypoxia with secondary atelectasis, pulmonary edema and pulmonary hypertension, and cerebral depression. Though the origin of the embolic fat is debated, there is evidence to support its origin from both the bone marrow and intravascular chylomicron coalescence.The clinical manifestations are largely explained by a prime assault upon the lung parenchyma and alteration in platelet characteristics.Early recognition and treatment of the condition is essential, adequate oxygenation being of prime importance. Steroids and heparin have been found to be of benefit.

Bone Marrow↗
PubMedDate not supplied

Cytomegalovirus retinitis.

Cytomegalovirus retinitis is a frequent and serious complication of various conditions, including diseases characterized by impaired immunity, such as the acquired immunodeficiency syndrome. Due to recent advances in the treatment of cytomegalovirus retinitis, accurate diagnosis and management have become increasingly important. In this review, the authors present the epidemiology, clinical features, diagnostic testing, treatment with complications, and prognosis of cytomegalovirus retinitis. A differential diagnosis is presented and the characteristic ocular lesions are illustrated.

Acquired Immunodeficiency Syndrome↗