Inability of degraded carrageenan fractions to induce inflammatory bowel ulceration in the guinea-pig.
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Animals↗
Biomedical subjects
A A Norris
Publications and source records attributed to A A Norris.
Studies on a cell-mediated immune response in the guinea-pig colon [proceedings].
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Animals↗
The effects of nedocromil sodium and sodium cromoglycate on airway nerves and neurogenic responses in asthma.
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Animals↗
Pharmacologic modulation of Th1 and Th2 cell subsets by nedocromil sodium.
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Animals↗
Role of chloride channel modulation in the mechanism of action of nedocromil sodium.
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3T3 Cells↗
Inhibitory effects of nedocromil sodium on cytokine production from mast and epithelial cells.
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3T3 Cells↗
[The effect of nedocromil sodium on the luminal-dependent chemiluminescence of whole-blood leukocytes].
Nedocromil sodium in concentrations of 10(-3) to 10(-9) M dose-dependently inhibits a zymosan (2 mg/ml)-induced chemiluminescence response (CLR) of whole blood leukocytes and, to a lesser extent, phorbol myrystate acetate (PMA)-induced CLR. The count of diformazan-positive granulocytes in the zymosan-induced nitroblue tetrazolium test slightly reduced in the presence of 10(5) nedocromil sodium. PMA in a dose of 10(-9) M did not induce CLR, but brought about leukocyte priming, thus sensitizing them to secondary triggering by suboptimal zymosan concentrations (0.5 mg/ml). A subsequent stimulation of leukocytes with PMA + zymosan demonstrated that nedocromil sodium (10(-7) M) inhibited mainly priming PMA rather than the zymosan-triggering step of leukocyte activation.
Adult↗