Some behavioural and EEG studies on the behavioural depression induced in the rat by ethanolamine O-sulphate, an inhibitor of GABA-transaminase [proceedings].
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Biomedical subjects
Publications and source records attributed to A A Miller.
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Folic acid applied topically in solution to the rat cuneate nucleus reduced presynaptic inhibition produced by peripheral stimulation. This resembles the action of picrotoxin in the same animals and it is possible that these two convulsants are acting in a similar manner by blockade of the receptors for the presynaptic inhibitory transmitter.
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The case reported showed acute necrotic myelopathy and acute perivenous encephalomyelitis against a background of renal infection, malignant hypertension, and a history of injury. Death from renal disease and pneumonia halted the neurological pathology in the acute stage, thus allowing a more detailed histological examination than is possible in the later stages. The pathogenesis of acute necrotic myelopathy, together with the effects of oedema and vascular compression in the cord, are discussed briefly.