[Problems and prospects of studies of the Helicobacter pylori infection].
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Biomedical subjects
Publications and source records attributed to A A Il'chenko.
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The article presents the recent information on pathology little known to general practitioners--biliary pancreatitis. The role of cholelithiasis in the formation of pancreas pathology is shown. Instrumental and laboratory methods of biliary pancreatitis diagnostics are assessed in detail. Taking into account the pathogenetic peculiarities of the biliary pancreatitis formation, a drug therapy that includes correction of biliary and exocrine pancreas insufficiency and maldigestion syndrome is presented.
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The surgical material of 1,340 cholecystectomies as a result of cholelithiasis was analyzed. Heterotopy of the stomach mucous membrane into gallbladder was discovered in two cases; its heterotopy into the common bile duct with an ulcer formed in the heterotopic section of the mucous membrane in the fundic part of stomach was discovered in one case.
23 patients with gall-bladder cholesterosis associated with cholesterol gallstones were treated with ursodeoxycholic acid preparations. A regression of cholesterol polyps was recorded in 56.5% against the background of treatment, and complete or partial dissolution of gallstones was observed in 87%. The efficiency of dissolution of cholesterol polyps and stones in the gall-bladder went up along with the extension of the therapy terms, reaching its maximum by 7-9 months of treatment. The dissolution rates were higher for gallstones than for cholesterol polyps. The volume of bile being secreted increased, and the gall-bladder contractile function improved in the course of treatment.
AIM: To specify characteristics of biochemical bile composition contributing to destabilization of colloid properties of bile in patients with biliary "sludge". MATERIAL AND METHODS: 37 patients with "sludge" in the gallbladder (GB), 10 patients with cholelithiasis and 10 patients with intact GB participating in the study were examined for bile portion B bile acids (BA), cholesterol and phospholipids (PL); lipid and lipoprotein blood composition. RESULTS: Three types of biochemical composition of bile in GB "sludge" patients were identified. 22 patients had elevated levels of cholesterol and PL in subnormal content of BA (group 1); 9 patients had normal FA and cholesterol, low content of biliary PL (group 2); 6 patients had normal concentrations of the three components (group 3). Blood lipids were characterized by elevated levels of total cholesterol and LDLP cholesterol in group 1; low HDLP cholesterol and triglycerides in group 2 and almost normal values in group 3. Basing on these data, causes of "sludge" formation in the GB are suggested. CONCLUSION: Biliary "sludge" may form because of excessive cholesterol in bile, low phospholipid levels or in normal proportion of the studied substances.
Cholelithiasis is one of the basic pathologies of the digestive apparatus. A certain progress in the study of biliary production and excretion processes has been achieved for the past two decades. This contributed to a deeper understanding of causes and factors promoting the formation of the lithogenic bile. Possibilities for cholelithiasis diagnostics (including precholelithiatic stages) have greatly expanded. The ultrasound method, which is quite efficient for diagnostics of cholecystolithiasis, has become a basic method of cholelithiasis diagnostics. Nevertheless, the course of cholelithiasis is not restricted to the formation of gallstones only. In 5-20% of cases cholecystolithiasis is combined with choledocholithiasis. The latest literature data related to problems of choledocholithiasis etiology, pathogenesis and diagnostics are given in this review of literature.
Stomach cancer will remain one of the most prevalent malignant neoplasms on a global scale and in the foreseeable future. Its etiology is considered to comprise many factors including damaging environmental factors, genetic disorders and risk factors of Helicobacter pylori infection.
The authors review current literature on etiology, pathogenesis and classification of biliary sludge (BS); they analyse factors promoting formation of BS and show that ultrasonic investigation is the key diagnostic method, detecting various forms of BS and differentiating BS with parietal new-growths of the gallbladder, evaluating function of the latter and controlling efficacy of conservative therapy. Follow-up results demonstrate that BS can disappear spontaneously, be persistent in a part of patients, form stones in 20% patients. Clinical picture in BS has no specific symptoms but in 33-75% cases it is associated with development of biliary pancreatitis as a results of secondary dysfunction of the Oddi's sphincter. The latest findings on efficacy of litholytic therapy in BS and data on possible use of nonsteroid anti-inflammatory drugs as inhibitors of mucin production to prevent recurrent cholelithiasis are presented.
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The article presents the latest literature data related to the problems of epidemiology, etiology, pathogenesis, morphological changes, diagnostics, classification, clinical coarse and treatment of gallbladder cholesterosis.
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