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Biomedical subjects

A A Hebert

Publications and source records attributed to A A Hebert.

67 records · Page 4Linked to original sources

Tinea faciei in infants caused by Trichophyton tonsurans.

Tinea faciei has been observed periodically in children, however, it is a relatively rare occurrence in infancy. We examined three infants with tinea faciei caused by Trichophyton tonsurans. Two of the patients were potassium hydroxide (KOH) negative for fungal hyphae but culture positive, while the third was both KOH and culture positive. Trichophyton tonsurans was isolated from the scalp of family members in two of the three infants.

Facial Dermatoses↗

Bacterial and candidal cutaneous infections in the neonate.

The skin and oral cavity of the neonate are colonized by a variety of organisms during the first few days of life. Some of these organisms constitute normal flora, but others are true pathogens or are capable of pathogenicity when host or environmental factors are altered in their favor. Cutaneous bacterial and yeast infections that afflict the newborn are discussed in terms of clinical presentation, laboratory evaluation, and appropriate management.

Bacterial Infections↗

Sacral hemangiomas and multiple congenital abnormalities.

Five infants with sacral hemangiomas and a particular constellation of congenital abnormalities are described. Three of the five infants had an imperforate anus associated with a fistula. Three of the five had renal anomalies; four had bony abnormalities of the sacrum, and three of these also had a lipomeningomyelocele. Four had skin tags, three of which were in the genital and sacral areas. Two of the five also had abnormalities of the external genitalia. This constellation of defects associated with a sacral hemangioma has not been, to our knowledge, elaborated previously.

Abnormalities, Multiple↗

Pyoderma gangrenosum and chronic persistent hepatitis.

Pyoderma gangrenosum is a diagnosis of exclusion. A 36-year-old woman was clinically diagnosed as having pyoderma gangrenosum and appropriate exclusion tests were performed. Pyoderma gangrenosum may occur in association with underlying diseases such as leukemia, monoclonal gammopathy, inflammatory bowel disease, arthritis, and chronic active hepatitis. However, these diseases were excluded in this patient who did have chronic persistent hepatitis. To our knowledge, this is the first reported case of chronic persistent hepatitis and pyoderma gangrenosum.

Adult↗

Trichostasis spinulosa.

Trichostasis spinulosa is a common disorder of follicular hyperkeratosis that is often confused clinically with similar disorders, such as keratosis pilaris and eruptive vellus hair cysts. Six patients from the UTMB dermatology clinic who had trichostasis spinulosa are presented. Two of the six also had keratosis pilaris and one had eruptive vellus hair cysts. The present study was undertaken to compare and contrast the clinical presentation and histopathologic appearance of these three disorders. The results of the study and review of the literature revealed differences in distribution of lesions and microscopic appearance of follicular and histopathologic material.

Adult↗

Tinea capitis caused by Trichophyton tonsurans.

Children with tinea capitis caused by Trichophyton tonsurans often have a lifetime of association with the organism and, in spite of intermittent therapy, as adults pass the infection to successive generations. While most current treatment regimens are directed at treating the individual patient, our study supports the need to evaluate and possibly treat all family members and their home environment.

Adolescent↗

Simultaneous occurrence of idiopathic lipemic tears and massive seborrhea.

A 42-year-old man had idiopathic lipemic tears and massive seborrhea. Recent investigations have shown that cholesterol and other lipids occasionally found in tears are produced by meibomian rather than lacrimal glands. The finding in this patient of hypersecretion by both sebaceous glands and meibomian glands, a sebaceous gland variant, suggests that a common mechanism may regulate secretory control of both of these glands.

Adult↗

Concanavalin A distinguishes among diseases of altered epidermal differentiation.

Mannose-containing of glycoproteins from lesional tissue of several diseases of aberrant epidermal differentiation (palmar-plantar keratoderma, pachyonychia congenita, psoriasis, and epidermolytic hyperkeratosis) were analyzed by overlaying iodinated concanavalin A onto molecules separated by polyacrylamide gel electrophoresis. Gel autoradiograms showed that biopsy samples from patients with the same disease were very similar. The radioactivity profiles were different for each disease and were distinguishable from each other and from normal epidermis and callus. The resolution and sensitivity of this technique may be of diagnostic significance.

Cell Differentiation↗

Bowel-bypass syndrome without bowel bypass. Bowel-associated dermatosis-arthritis syndrome.

A recurrent, episodic illness that occurs in as many as 20% of patients who undergo ileojejunal bypass surgery for morbid obesity has been well characterized and includes inflammatory cutaneous lesions with a histologic appearance like that of neutrophilic vasculitis, a nondeforming polyarthritis, and other systemic manifestations. Current concepts of pathogenesis center on overgrowth of bacterial flora in the bypassed bowel segment with subsequent development of a circulating immune complex disease. We report, for the first time to our knowledge, an identical clinicopathologic syndrome in four patients who have not had jejunoileal bypass surgery. Each patient, however, had other gastrointestinal disease that we believe predisposed to this syndrome, possibly via circulating immune complexes with bowel-associated antigens. We propose the expanded term, bowel-associated dermatosis-arthritis syndrome, to incorporate these new cases. We believe that this is not a rare syndrome and that it is easily distinguishable from other types of cutaneous necrotizing vasculitis.

Adult↗

Malignant rhabdoid tumor presenting as a hemangioma.

Malignant rhabdoid tumor is a rare and highly aggressive malignancy of unknown etiology. We report a primary cutaneous rhabdoid tumor on the upper back of a newborn. It was initially diagnosed as a hemangioma clinically, and that diagnosis was supported by radiologic studies, including magnetic resonance imaging. However, detailed investigation with light microscopy, immunohistochemistry, and electron microscopy enabled us to make a diagnosis of rhabdoid tumor. This is the seventh reported case of rhabdoid tumor with primary cutaneous involvement.

Antineoplastic Combined Chemotherapy Protocols↗